Biblical Characters: 1 character
Isaac   (m)   Gen. 21:1  
Coptic Popes and Patriarchs of Alexandria: 1 pope
Isaac I   690-692  
Dutch Prime Ministers: 1 prime minister
Isaäc Dignus Fransen van de Putte   1866  
Emmy Award Winners: 1 actor
(actor) Sid Caesar (a.k.a. Isaac)   1952; 1957   ; Caesar's Hour  
Fictional Characters from Television: 2 characters
Zack Brady (middle name Isaac)   1965   Days of Our Lives  
Isaac Mendez   2006   Heroes  
Hall-of-Famers: 1 football
(football) Isaac Bruce   2020  
Hurricanes and Tropical Storms: 4 hurricanes, 1 storm
Storm Isaac   1988  
Hurricane Isaac   2000  
Hurricane Isaac   2006  
Hurricane Isaac   2012  
Hurricane Isaac   2018  
Israeli Presidents and Prime Ministers: 1 president
(president) Isaac Herzog   2021-  
Nobel Prize Winners: 2 physics, 1 literature
(physics) Isidor Isaac Rabi   1944  
(literature) Isaac Bashevis Singer   1978  
(physics) Jerome Isaac Friedman   1990  
Notable Actors and Entertainers: 5 actors, 1 actor/comedian
Chief John Big Tree (a.k.a. Isaac)   1877-1967  
Sid Caesar (a.k.a. Isaac)   1922-2014  
Jerry Stiller (middle name Isaac)   1927-2020  
Liev Schreiber (a.k.a. Isaac)   1967-  
Oscar Isaac   1979-  
Isaac Hempstead-Wright   1999-  
Notable Artists: 1 painter
Isaac Levitan   1860-1900  
Notable Athletes: 1 cricket, 1 rugby, 1 soccer
(cricket) Viv Richards (a.k.a. Isaac)   1952-  
(rugby) Isaac Boss   1980-  
(soccer) Isaác Brizuela   1990-  
Notable Musicians: 2 musicians, 1 composer, 1 musician/singer, 1 singer
Isaac Albéniz   1860-1909  
Don Everly (a.k.a. Isaac)   1937-2021  
Isaac Hayes   1942-2008  
Isaac Hanson   1980-  
Isaac Slade   1981-  
Notable Philosophers and Thinkers: 1 mathematician
Isaac Newton   1642-1727  
Notable Politicians and Statespeople: 1 politician
Adolphe Crémieux (a.k.a. Isaac)   1796-1880  
Notable Scientists and Inventors: 3 physicists, 1 inventor
Isaac Newton   1642-1727  
Isaac Singer   1811-1875  
Isidor Isaac Rabi   1898-1988  
Jerome Isaac Friedman   1930-  
Notable Writers: 2 authors
Isaac Bashevis Singer   1902-1991  
Isaac Asimov   1920-1992  
Olympic Medalists: 1 bronze, 1 gold, 1 silver
(gold) Isaac Bentham   1912   water polo  
(silver) James Wendell (middle name Isaac)   1912   110 m hurdles  
(bronze) Isaac Makwala   2020   4x400 m relay  
Rock and Roll Hall-of-Famers: 2 musicians
Don Everly (a.k.a. Isaac)   1986     
Isaac Hayes   2002     
Roman and Byzantine Emperors: 2 emperors
Emperor Isaac Comnenus   1057-1059  
Emperor Isaac Angelus; Isaac II Angelus   1185-1195; 1203-1204  
Saints: 3 saints
Saint Isaac of Constantinople   ?-410  
Saint Isaac of Spoleto   ?-550  
Saint Isaac of Cordoba   824-851