Namesakes
Biblical Characters:
1 character
Isaac (m) Gen. 21:1 
Isaac I 690-692
Dutch Prime Ministers:
1 prime minister
Isaäc Dignus Fransen van de Putte 1866
Emmy Award Winners:
1 actor
(actor) Sid Caesar (a.k.a. Isaac) 1952; 1957 ; Caesar's Hour
Fictional Characters from Television:
2 characters
Zack Brady (a.k.a. Isaac) 1965 Days of Our Lives
Isaac Mendez 2006 Heroes
Hall-of-Famers:
1 football
(football) Isaac Bruce 2020
Hurricanes and Tropical Storms:
4 hurricanes, 1 storm
Storm Isaac 1988
Hurricane Isaac 2000
Hurricane Isaac 2006
Hurricane Isaac 2012
Hurricane Isaac 2018
Israeli Presidents and Prime Ministers:
1 president
(president) Isaac Herzog 2021-
Nobel Prize Winners:
2 physics, 1 literature
(physics) Isidor Isaac Rabi 1944
(literature) Isaac Bashevis Singer 1978
(physics) Jerome Isaac Friedman 1990
Notable Actors and Entertainers:
5 actors, 1 actor/comedian
Chief John Big Tree (a.k.a. Isaac) 1877-1967
Sid Caesar (a.k.a. Isaac) 1922-2014
Jerry Stiller (a.k.a. Isaac) 1927-2020
Liev Schreiber (a.k.a. Isaac) 1967-
Oscar Isaac 1979-
Isaac Hempstead-Wright 1999-
Notable Artists:
1 painter
Isaac Levitan 1860-1900
Notable Athletes:
1 cricket, 1 rugby, 1 soccer
(cricket) Viv Richards (a.k.a. Isaac) 1952-
(rugby) Isaac Boss 1980-
(soccer) Isaác Brizuela 1990-
Notable Musicians:
2 musicians, 1 composer, 1 musician/singer, 1 singer
Isaac Albéniz 1860-1909
Don Everly (a.k.a. Isaac) 1937-2021
Isaac Hayes 1942-2008
Isaac Hanson 1980-
Isaac Slade 1981-
Notable Philosophers and Thinkers:
1 mathematician
Isaac Newton 1642-1727
Notable Politicians and Statespeople:
1 politician
Adolphe Crémieux (a.k.a. Isaac) 1796-1880
Notable Scientists and Inventors:
3 physicists, 1 inventor
Isaac Newton 1642-1727
Isaac Singer 1811-1875
Isidor Isaac Rabi 1898-1988
Jerome Isaac Friedman 1930-
Notable Writers:
2 authors
Isaac Bashevis Singer 1902-1991
Isaac Asimov 1920-1992
Olympic Medalists:
1 bronze, 1 gold, 1 silver
(gold) Isaac Bentham 1912 water polo
(silver) James Wendell (a.k.a. Isaac) 1912 110 m hurdles
(bronze) Isaac Makwala 2020 4x400 m relay
Rock and Roll Hall-of-Famers:
2 musicians
Don Everly (a.k.a. Isaac) 1986
Isaac Hayes 2002
Roman and Byzantine Emperors:
2 emperors
Emperor Isaac Comnenus 1057-1059
Emperor Isaac Angelus; Isaac II Angelus 1185-1195; 1203-1204
Saints:
3 saints
Saint Isaac of Constantinople ?-410
Saint Isaac of Spoleto ?-550
Saint Isaac of Cordoba 824-851