Namesakes
Isaac Newton
(m) 1642-1727 
Notable Philosophers and Thinkers
Notable Scientists and Inventors
Isaac Asimov
(m) 1920-1992
Notable Writers
Isaac Bashevis Singer
(m) 1902-1991
Nobel Prize Winners 1978 (literature)
Notable Writers
Isidor Isaac Rabi
(m) 1898-1988
Nobel Prize Winners 1944 (physics)
Notable Scientists and Inventors
Isaac
(m)
Biblical Characters Gen. 21:1
Jerome Isaac Friedman
(m) 1930-
Nobel Prize Winners 1990 (physics)
Notable Scientists and Inventors
Isaac Comnenus
(m) c. 1007-1061
Roman and Byzantine Emperors 1057-1059
Isaac Albéniz
(m) 1860-1909
Notable Musicians
Isaac Angelus; Isaac II Angelus
(m) 1156-1204
Roman and Byzantine Emperors 1185-1195; 1203-1204
Isaac Levitan
(m) 1860-1900
Notable Artists
Isaac Singer
(m) 1811-1875
Notable Scientists and Inventors
Isaac Herzog
(m) 1960-
Israeli Presidents and Prime Ministers 2021- (president)
Isaac Hayes
(m) 1942-2008
Notable Musicians
Rock and Roll Hall-of-Famers 2002
Oscar Isaac
(m) 1979-
Notable Actors and Entertainers (actor)
Liev Schreiber
(a.k.a. Isaac) (m) 1967-
Notable Actors and Entertainers (actor)
Jerry Stiller
(middle name Isaac) (m) 1927-2020
Notable Actors and Entertainers (actor/comedian)
Isaac Hempstead-Wright
(m) 1999-
Notable Actors and Entertainers (actor)
Sid Caesar
(a.k.a. Isaac) (m) 1922-2014
Emmy Award Winners 1952; 1957 ; Caesar's Hour (actor)
Notable Actors and Entertainers (actor)
Isaac Hanson
(m) 1980-
Notable Musicians
Isaác Brizuela
(m) 1990-
Notable Athletes (soccer)
Isaac of Cordoba
(m) 824-851
Saints
Isaac Makwala
(m) 1985-
Olympic Medalists 2020 4x400 m relay (bronze)
Viv Richards
(a.k.a. Isaac) (m) 1952-
Notable Athletes (cricket)
Adolphe Crémieux
(a.k.a. Isaac) (m) 1796-1880
Notable Politicians and Statespeople
James Wendell
(middle name Isaac) (m) 1890-1958
Olympic Medalists 1912 110 m hurdles (silver)
Isaac Bentham
(m) 1886-1917
Olympic Medalists 1912 water polo (gold)
Isaäc Dignus Fransen van de Putte
(m) 1822-1902
Dutch Prime Ministers 1866
Isaac Slade
(m) 1981-
Notable Musicians
Isaac
(m)
Hurricanes and Tropical Storms 2012 (hurricane)
Chief John Big Tree
(a.k.a. Isaac) (m) 1877-1967
Notable Actors and Entertainers (actor)
Isaac I
(m) 6xx-692
Coptic Popes and Patriarchs of Alexandria 690-692
Isaac Boss
(m) 1980-
Notable Athletes (rugby)
Isaac
(m)
Hurricanes and Tropical Storms 2006 (hurricane)
Isaac Bruce
(m) 1972-
Hall-of-Famers 2020 (football)
Don Everly
(a.k.a. Isaac) (m) 1937-2021
Notable Musicians
Rock and Roll Hall-of-Famers 1986
Isaac
(m)
Hurricanes and Tropical Storms 2000 (hurricane)
Isaac Mendez
(m)
Fictional Characters from Television 2006 Heroes
Zack Brady
(middle name Isaac) (m)
Fictional Characters from Television 1965 Days of Our Lives
Isaac of Constantinople
(m) ?-410
Saints
Isaac of Spoleto
(m) ?-550
Saints
Isaac
(m)
Hurricanes and Tropical Storms 1988 (storm)
Isaac
(m)
Hurricanes and Tropical Storms 2018 (hurricane)