Namesakes
Characters in Greek Mythology:
1 character
Eirene (a.k.a. Irene) (f) 
Fictional Characters from Books:
3 characters
Irene Adler 1891 A Scandal in Bohemia
Carreen O'Hara (a.k.a. Irene) 1936 Gone With the Wind
Irène Verhœven 2006 Irène
Fictional Characters from Movies:
1 character
Carreen O'Hara (a.k.a. Irene) 1939 Gone With the Wind
Fictional Characters from Plays and Musicals:
1 character
Irene O'Dare 1919 Irene
Fictional Characters from Song Titles:
4 characters
(character) Irene 1950 Goodnight, Irene
(character) Irene Wilde 1976 Irene Wilde
(character) Christine Irene 1994 Christine Irene
(character) Irene 2014 Irene
Fictional Characters from Television:
2 characters
Irene Daniels 2005 The Closer
Melinda Gordon (a.k.a. Irene) 2005 Ghost Whisperer
Hurricanes and Tropical Storms:
5 hurricanes, 1 storm
Storm Irene 1959
Hurricane Irene 1971
Hurricane Irene 1981
Hurricane Irene 1999
Hurricane Irene 2005
Hurricane Irene 2011
Nobel Prize Winners:
1 chemistry
(chemistry) Irène Joliot-Curie 1935
Notable Actors and Entertainers:
12 actors, 2 actor/models, 1 reality star
Irene Rich 1891-1988
Irene Dunne 1898-1990
May McAvoy (a.k.a. Irene) 1899-1984
Irene Ryan 1902-1973
Irene Hervey 1909-1998
Katie Boyle (a.k.a. Irene) 1926-2018
Capucine (a.k.a. Irène) 1928-1990
Irene Papas 1929-2022
Irène Tunc 1934-1972
Lois Hamilton (a.k.a. Irene) 1943-1999
Irene Cara 1959-2022
Irene Bedard 1967-
Lisa Chappell (a.k.a. Irene) 1968-
Kate Gosselin (a.k.a. Irene) 1975-
Emily VanCamp (a.k.a. Irene) 1986-
Notable Athletes:
1 skating
(skating) Irene Schouten 1992-
Notable Filmmakers:
1 director
Sophie Hunter (a.k.a. Irene) 1978-
Notable Musicians:
2 singers
Irene Cara 1959-2022
Irene 1991-
Notable Scientists and Inventors:
1 chemist
Irène Joliot-Curie 1897-1956
Notable Writers:
1 author
Irène Némirovsky 1903-1942
Olympic Medalists:
4 bronze, 1 gold, 1 silver/gold
(gold) Irene Steer 1912 swimming - 4x100 m freestyle relay
(silver/gold) Irene Guest 1920 swimming - 100 m freestyle; swimming - 4x100 m freestyle relay
(bronze) Irene MacDonald 1956 diving - springboard
(bronze) Martha Randall (a.k.a. Irene) 1964 swimming - 400 m medley
(bronze) Irene de Kok 1992 judo
(bronze) Irene Montrucchio 2012 synchronized swimming - team
Other Royalty:
2 princesses, 1 queen consort
Alexandrine of Prussia (a.k.a. Irene) 1915-1980 Prussia
Irene of the Netherlands 1939- Netherlands
Louise of Sweden (a.k.a. Irene) 1950-1965 Sweden
Roman and Byzantine Emperors:
1 empress
Empress Irene Sarantapechaina 797-802
Saints:
4 saints
Saint Irene ?-286
Saint Irene of Thessalonica ?-304
Saint Irene ?-379
Saint Irene ?-653