I think this name is really cool, it has a lot of personality and reminds me of the hit film Space Buddies where the cosmonaut from Russia is called Yuri. I really like that film, it has talking dogs in it.
As much as I love the name, I agree that it reminds me of the lesbian genre of manga a bit too much for me to ever recommend using it. Perhaps as a middle name, it could work better.
Be careful with this one -- "Yuri" is slang for often rather R-rated lesbian manga and anime (a term used primarily in the US rather than in Japan). I love the name Yuri, but personally I wouldn't use it for the above reason.
In my opinion, a very masculine name for a boy, with this pronunciation. I'd love to name my kid Yury (because it looks more masculine), but I fear people would still think it sounded girly.