Namesakes
Grammy Award Winners:
1 song of the year/record of the year
(song of the year/record of the year) Domenico Modugno 1959 Nel blu, dipinto di blu (Volare) 
Notable Artists:
1 fashion designer, 1 painter
Domenico Ghirlandaio 1449-1494
Domenico Dolce 1958-
Notable Businesspeople:
1 businessperson
Domingo Ghirardelli (a.k.a. Domenico) 1817-1894
Notable Musicians:
2 singers, 1 composer
Domenico Scarlatti 1685-1757
Domenico Modugno 1928-1994
Nino de Angelo (a.k.a. Domenico) 1963-
Notable Philosophers and Thinkers:
1 mathematician
Giovanni Domenico Cassini 1625-1712
Notable Scientists and Inventors:
1 astronomer
Giovanni Domenico Cassini 1625-1712
Olympic Medalists:
1 bronze, 1 gold
(bronze) Domenico Giambonini 1920 shooting
(gold) Domenico Fioravanti 2000 swimming - 100 m breaststroke; swimming - 200 m breaststroke
Saints:
3 blessed, 1 saint
Blessed Domenico Spadafora ?-1521
Blessed Domenico Lentini 1770-1828
Blessed Dominic Barberi (a.k.a. Domenico) 1792-1849
Saint Domenico Savio 1842-1857