Namesakes
Domenico Ghirlandaio
(m) 1449-1494 
Notable Artists
Domenico Spadafora
(m) ?-1521
Saints
Giovanni Domenico Cassini
(m) 1625-1712
Notable Philosophers and Thinkers
Notable Scientists and Inventors
Domenico Scarlatti
(m) 1685-1757
Notable Musicians
Domenico Lentini
(m) 1770-1828
Saints
Dominic Barberi
(a.k.a. Domenico) (m) 1792-1849
Saints
Domingo Ghirardelli
(a.k.a. Domenico) (m) 1817-1894
Notable Businesspeople
Domenico Savio
(m) 1842-1857
Saints
Domenico Giambonini
(m) 1868-1956
Olympic Medalists 1920 shooting (bronze)
Domenico Modugno
(m) 1928-1994
Grammy Award Winners 1959 Nel blu, dipinto di blu (Volare) (record of the year/song of the year)
Notable Musicians
Domenico Dolce
(m) 1958-
Notable Artists
Nino de Angelo
(a.k.a. Domenico) (m) 1963-
Notable Musicians
Domenico Fioravanti
(m) 1977-
Olympic Medalists 2000 swimming - 100 m breaststroke; swimming - 200 m breaststroke (gold)