Save Gender Feminine Usage English (Modern, Rare) Pronounced Pron. sis-TEEN [key] Other Forms FormsSistina Meaning & History From the name of the Sistine Chapel, which is derived from Sisto and named for Pope Sixtus IV, who had it built. This is borne by Sistine Stallone (1998-), a daughter of the actor Sylvester Stallone.
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