Namesakes
Fictional Characters from Books:
1 character
Santiago 1952 The Old Man and the Sea 
Nobel Prize Winners:
1 medicine
(medicine) Santiago Ramón y Cajal 1906
Notable Actors and Entertainers:
1 actor
Santiago Cabrera 1978-
Notable Athletes:
3 soccer, 1 rugby, 1 tennis
(soccer) Santiago Bernabéu 1895-1978
(tennis) Santiago González 1983-
(soccer) Santi Cazorla 1984-
(rugby) Santiago González Iglesias 1988-
(soccer) Santiago Arias 1992-
Notable Politicians and Statespeople:
1 politician
Santiago Abascal 1976-
Notable Scientists and Inventors:
1 biologist
Santiago Ramón y Cajal 1852-1934
Olympic Medalists:
2 bronze
(bronze) Santiago Chalmovsky 1984 water polo
(bronze) Freddy Mayola (a.k.a. Santiago) 2000 4x100 m relay
Saints:
1 blessed
Blessed Santiago Mestre Iborra de Rafelbunyol 1909-1936
Spanish Prime Ministers:
1 prime minister
Santiago Casares Quiroga 1936