Namesakes
Fictional Characters from Television:
1 character
Carl Winslow (a.k.a. Otis) 1986; 1989 Perfect Strangers; Family Matters 
Notable Musicians:
2 musicians
Otis Rush 1934-2018
Otis Redding 1941-1967
Olympic Medalists:
2 silver/gold, 1 gold
(gold) Otis Davis 1960 400 m; 4x400 m relay
(silver/gold) Paul Drayton (a.k.a. Otis) 1964 200 m; 4x100 m relay
(silver/gold) Otis Harris Jr. 2004 400 m; 4x400 m relay
Rock and Roll Hall-of-Famers:
2 musicians
Otis Redding 1989
Otis Williams 1989 The Temptations