Save Gender Feminine Usage Spanish Pronounced Pron. /ma.ˈɾi.a.de.los.ˌsan.tos/ [key·simplify] Meaning & History Means "Mary of the Saints" in Spanish.It is used in reference to the Spanish Marian title Nuestra Señora Reina de Todos los Santos, which translates as Our Lady, Queen of All Saints in English. Shortened forms including María Santos and Santos.