Marfisa d'Este (c.1554 – 1608) was a Ferrarese (Italian) noblewoman. She was the illegitimate daughter of Francesco d'Este and Maria Folch de Cardona. She and her sister Bradamante (born 1559) were legitimised by both pope Gregory XIII and Alfonso II d'Este. She was also notable as a patron of the arts and the protector of Torquato Tasso.