Manus derives from the adjective 'Magnus' which, in Latin, means great. The word Manus in Latin does, of course, mean 'hand' (as in manual work etc.) This, however, is not the origin of the name Manus. While magnus means great, maior or major means 'greater' Maximus means 'greatest'.
Manus is a Latin word - means hand (singular) and plural means Band of Men. The name Manus originates in Donegal Ireland for Irish names. Manus is a Sanskrit word which means "mind". This name is common in Thailand and India.