Esmerelda "Esme" Weatherwax (also Granny Weatherwax or Mistress Weatherwax) is a fictional character from Terry Pratchett's Discworld series. See: https://en.wikipedia.org/wiki/Granny_Weatherwax
Esme Timbery (also known by her married name, Russell) is a Bidjigal (First Nations Australian) shellworker and artist. Timbery's shellwork has contemporary elements, blended with the traditional medium. She has work in the collections of several art museums throughout Australia. A building at the University of New South Wales has been named in honour of Timbery, the Esme Timbery Creative Practice Lab (ETCPL). The building is decorated with a mural titled 'In her hands' and it is the first building at the University named after an Aboriginal woman.
Esme Young is an English fashion designer and television presenter. Since 2016, she has been a judge on the BBC reality series The Great British Sewing Bee.
Mrs. Esme Cordelia Hoggett is the wife of Farmer Arthur Hoggett and the owner of Babe the sheep pig who appeared in Babe and Babe: Pig in the City. She is played by Magda Szubanski.
There is a character named Esme in the A Series of Unfortunate Events book series. She's the guardian of the Baudelaires in The Ersatz Elevator and Count Olaf's girlfriend from The Ersatz Elevator until The Penultimate Peril.