Namesakes
Fictional Characters from Television:
2 characters
Lucas Horton (a.k.a. Desmond) 1965 Days of Our Lives 
Desmond Hume 2004 Lost
Nobel Prize Winners:
1 peace
(peace) Desmond Tutu 1984
Notable Activists and Revolutionaries:
1 activist
(activist) Desmond Tutu 1931-2021
Notable Actors and Entertainers:
4 actors
William Desmond Taylor 1872-1922
Desmond Llewelyn 1914-1999
Glyn Houston (a.k.a. Desmond) 1925-2019
Desmond Harrington 1976-
Notable Athletes:
1 football
(football) Dez Bryant 1988-
Notable Filmmakers:
1 director
William Desmond Taylor 1872-1922
Olympic Medalists:
1 bronze, 1 silver
(bronze) Des Koch 1956 discus throw
(silver) Jai Taurima (a.k.a. Desmond) 2000 long jump
Other Leaders:
1 president
President Desmond Hoyte 1985-1992 Guyana