I've never knowingly seen
Winona Ryder, though I am aware that she exists - mostly because I've always enjoyed the name
Winona. I've never met anyone with the name, and never seen a reference where I live to anyone with it. So my associations are with the old lady in
Hiawatha, and with a name that could shorten to Win(nie) without being
Winifred.
As for whether it's usable because of one actress ... why not? Look at all the
Cameron people, and the rather older
Marilyn people. Nobody even twitches.