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Some examples from the Web of persons using Isaac as a surname:

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http://www.google.com/#hl=en&q=%22mike+isaac%22&aq=f&aqi=g1&aql=&oq=%22mike+isaac%22&gs_rfai=&fp=ca6b5a4f84435186

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http://www.linkedin.com/pub/dir/Michael/Isaac/

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http://names.whitepages.com/Mary/Isaac

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http://www.allbusiness.com/finance/4504247-1.html

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So yes, Isaac is obviously a surname in regular use. :)