Sorry to be blunt, but it seems like for an American English speaker, it'd come out too often sounding a lot like Scooby-Doo saying
Alexandra. Ruh-roh. That's just what the look of it reminds me of. Even the Rou-ks sound would, IMO, be too awkward for speakers such as myself.
Rusandra appears, according to a Google search, to be an alternate form somewhere. I like that better - prn roo SAHN dra.
May be that's how
Ruxandra is pronounced too? I don't know.
I hope you don't mind, I've just made a note on my own list of Russandra (I'm pronouncing it roo-SAN-dra), since that comes up on Google as a fantasy character name =D
No middles coming to mind at the moment...
- mirfak