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I've never personally known someone named Buffy. But there is a person on one of the Animal Cops shows(Miami, I think), who goes by Buffy, even though her name is Deirdre.

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My Grandma also had a cat named Buffy who was evil and the only cat ever really in the family.

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Personally, I would never use the name Buffy, as it will always be associated with the evil cat and the tv show for me.