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I'd laugh, probably. It's a one-off name and is already solely associated with Sherlock Holmes.
Also, the only time I ever hear people being called Sherlock is sarcastically, when somebody's said or done something very dumb; example, watching the news last night, the anchor introduced a story about a teenage tennis player who came out of nowhere to be a champion. He opened with something like "If you've never heard of Tina Tennisplayer before, this will be the first you've heard of her." Very clumsy and poorly-worded intro, and my husband muttered "No sh**, Sherlock!"