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It sounds like a chemical. I think there is an enzyme called pepsin, that's probably what I'm thinking of.

I quite like it. I don't know if it's usable in England though. Where I live (Belgium) it certainly would be, but Pepijn is used more frequent here.

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Possible middle names:

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Pepin Jonah
Pepin Isaiah
Pepin August
Pepin Gus
Pepin Arthur
Pepin Amos

Actually, it reminds me of Laura Ingalls Wilder. The reason is because she was born/lived near Pepin, Wisconsin very early in her life. As a name, I think it's too Hobbit-like and precious and twee. Sorry.

I didn't know it was anybody's name till just now.
No, I don't. I think it sounds like an antacid, and also Pep and Peppy would be dumb even for a dog.

It's usable, but Pippin is nicer.
I'd pair it with an honouring name, or a name that's a bit more classic and nicknameable, so he can use that if he doesn't like Pepin or one of it's nns (which would be Pep or Pin):

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James "Jim" or "Jamie"
William "Will" "Bill" "Billie / Billy" or "Liam"
Alexander / Alexandre / Alexandro / Alessandro etc. "Alex" "Xander" "Sandro" etc.
Andrew "Drew" or "Andy"
Anthony "Tony"
Joseph "Joe" or "Joey"
Charles "Charlie"
Dominic "Dom"
Matthew / Matteo / Mateo / Mattheus / Matthias etc. "Matt" or "Mat"
Christopher "Chris" or "Topher"
Elijah "Eli"
Henry "Harry"
Lucas "Luke"
Marcus "Mark" or "Marc"
Oliver "Ollie"
Ronald "Ron"