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Persie, of course, and Seph; I'm afraid that Phoney could also feature.

Posy is the only one I can think of that hasn't been mentioned yet.

Sephy.

Onee/Oney/Onie? (all pronounced like own-ee) Eh, something different ;o) I love the name Persephone, though, and if I named a daughter this, I would probably ended up nicknaming her Seph/Sephie.

Persa
Sephie
Penny
Effie

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I think Sephie might be better, because it keeps the feel of Persephone and doesn't look too contrived.

Penny, Poppy, Sephy, Persey

Perse (pronounced like PUR-see; the person I knew with this name had this nickname)
Seph / Sephie
Perry's also a possibility too.

Sephi! Sephi is my favorite, but you could also use Perry or Honey.

Seph
Sephie
Sepha
Persie / Percy

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I like Seph and Sephie the best.

Peri / Perry
Sephie
Seph
I think Sophe / Sophie could work
Poppy
Penny
Percy / Persi
Ephie / Effie
Oni

Sephie is my favorite nn, but Perry or Peri could also work.

I like Persi / Percy / Percie myself, but Effie could also be cute.