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Surname in brackets:
Jensen Ross (Ackles) has an older brother Joshua and younger sister Mackenzie.
Thomas John Patrick (Welling) has 2 older sisters Rebecca and Jamie and a younger brother Mark.
Thomas Cruise IV (Mapother) has 3 sisters, Lee Anne, Marian and Cass
Channing Bryan Isaac Tatum (Anderson).
Jared Tristan (Padalecki) has an older brother Jeff and younger sister Megan.
John Christopher (Depp) has a brother Daniel P and sisters Christie and Debbie.
Matthew Paige (Damon) has a brother Kyle.
Benjamin Geza (Affleck) has brother Caleb Casey.
Jennifer Lynn (Lopez) has sisters Leslie and Lynda.
Jennifer Anne (Garner) has sisters Melissa and Susannah.
Kimberley Alexis (Bledel) has a brother Eric David.
Julia Fiona (Roberts) has a brother Eric and sisters Lisa and Nancy.
Matthew Ryan (Phillippe) has sisters Kirsten, Lindsay and Katelyn.
Laura Jeanne Reese (Witherspoon) has a brother John Draper.
Alicia Christian ('Jodie' Foster) has sisters Lucinda and Constance and a brother Lucius.
John Joseph (Travolta) has brothers Joey and Sam and sisters Ellen, Ann and Margaret.

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And the most interesting set:
Uma Karuna (Thurman) has a sister Taya and brothers Ganden, Dechen and Mipam.