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I personally like both, but my love for the name really began with a dear mentor by the name of Louise. I think Louise sounds more "old-lady-ish" than Louisa, which seems more classic. My only problem with it is the EEZE sound at the end of the name which is rather annoying to me in the same way as ZANN at the end of Suzanne. I would personally use it as a middle name, and my current favorite combo is Anna Josephine Louise.