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No idea how they were pronounced when they were fresh and new ... but in English we'd usually say EYE-sis unless we were singing Mozart, in which case we'd use the continental version: EE-sis.

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Similarly, in English we'd say eye-ZI-a (that's the same vowel sound in the first two syllables, folks - wish this keyboard could do the IPA!) unless we were acting in Guys and Dolls, where it seems to be eye-ZEY-a with the stressed syllable rhyming with way and hey. I don't know if this is widespread in the USA!

In French, Isis = ee-zis, and Isaiah = ee-za-ya. :)

ISIS f
Usage: Egyptian Mythology (Hellenized)
Pronounced: IE-sis

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ISAIAH m
Usage: English, Jewish, Biblical
Pronounced: ie-ZAY-a, ie-ZIE-a

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Perhaps Isis is pronounced differently, however, in French.

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Miranda