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I used to know an Ysela who was Hispanic who pronounced her name the same way as Isela. I don't know very much about Isela / Ysela, but I do know that it is used at least somewhat regularly in Hispanic communities.

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I highly doubt that Isela is related to Isla. I really don't know for sure, but I think that it's more likely to be related to Isolde and Yseult, a French form of Isolde, or Isabel / Isabelle / Ysabel, etc. I'm only guessing though!