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Drusilla reminds me of a) Caligula's sister, and b) the insane vampire in Buffy. However, I actually went to school with one, who spelt it Druscilla. She was not at all evil or mad, but very clever, captain of various societies, and possibly even Head Girl, but I can't remember that far back. :)
I like it, and Dru is nice, but the first two Drusillas would definitely put me off using it.