In the English-speaking world this name is more commonly given to girls. This is due to the American actress Alexis Smith (1921-1993), who began appearing in movies in the early 1940s. It got a boost in popularity in the 1980s from a character on the soap opera Dynasty.
The daughter of Zeus, she was said to have sprung from his head fully grown after he impregnated and swallowed her mother Metis. Athena is associated with the olive tree and the owl.
In the United States it became more common for girls in the early 1980s, shortly after the debut of the television sitcom The Facts of Life (1979-1988), which featured a character named Blair Warner. The name left the American top 1000 rankings two decades later, but was resurrected by another television character, this time Blair Waldorf from the series Gossip Girl (2007-2012).
This was a popular name in the 20th century (especially the middle decades) in French, German, and English-speaking countries. In the United States Christina has been more common since 1973, though both forms are currently floundering on the charts.
It was rare as an American given name before 1975. In the mid-1980s it began growing in popularity for boys after a character by this name began appearing on the soap opera Ryan's Hope. It is now more common as a feminine name, probably due to the fame of the actress Dakota Fanning (1994-).
A famous bearer of the surname was James Madison (1751-1836), one of the authors of the American constitution who later served as president (and after whom Madison Avenue was named).