In the United States this form was much less common than Isabel until the early 1990s, when it began rapidly rising in popularity. It reached a peak in 2009 and 2010, when it was the most popular name for girls in America, an astounding rise over only 20 years.
A famous bearer is the Italian actress Isabella Rossellini (1952-).
In England, it began to be used as a given name after the Protestant Reformation. It was moderately common in the 19th century. It began to rise in popularity again in the late 1980s, probably helped along by characters on the American television shows Friends (1994-2004) and Charmed (1998-2006). It is currently much more common in the United Kingdom, Australia and New Zealand than the United States.
A moon of Saturn bears this name, in honour of the Titan.