This name was not particularly common in Western Europe during the Middle Ages. It became more popular in part due to the fame of Prince Eugene of Savoy (1663-1736), a French-born general who served the Austrian Empire. A notable bearer was the American playwright Eugene O'Neill (1888-1953).
This name can also be given in reference to the city in Italy, as in the case of Florence Nightingale (1820-1910), who was born there to British parents. She was a nurse in military hospitals during the Crimean War and is usually considered the founder of modern nursing.