The name was common in France during the Middle Ages, and was introduced from there to England, though it eventually became rare. Interest in it was revived by the character Melanie Wilkes from the novel Gone with the Wind (1936) and the subsequent movie adaptation (1939).
In England, it began to be used as a given name after the Protestant Reformation. It was moderately common in the 19th century. It began to rise in popularity again in the late 1980s, probably helped along by characters on the American television shows Friends (1994-2004) and Charmed (1998-2006). It is currently much more common in the United Kingdom, Australia and New Zealand than the United States.
A moon of Saturn bears this name, in honour of the Titan.