The name became regularly used in the Christian world due to the fame of Saint Anthony the Great, a 4th-century Egyptian hermit who founded Christian monasticism. Its popularity was reinforced in the Middle Ages by the 13th-century Saint Anthony of Padua, the patron saint of Portugal. It has been commonly (but incorrectly) associated with Greek ἄνθος (anthos) meaning "flower", which resulted in the addition of the h to this spelling in the 17th century.
The popularity of the saint led to the name being used by nine Byzantine emperors, including Michael VIII Palaeologus who restored the empire in the 13th century. It has been common in Western Europe since the Middle Ages, and in England since the 12th century. It has been borne (in various spellings) by rulers of Russia (spelled Михаил), Romania (Mihai), Poland (Michał), and Portugal (Miguel).
In the United States, this name rapidly gained popularity beginning in the 1930s, eventually becoming the most popular male name from 1954 to 1998. However, it was not as overwhelmingly common in the United Kingdom, where it never reached the top spot.
Famous bearers of this name include the British chemist/physicist Michael Faraday (1791-1867), musician Michael Jackson (1958-2009), and basketball player Michael Jordan (1963-).