This name appears in the New Testament belonging to a companion of Saint Paul. He became the first bishop of Crete and was the recipient of one of Paul's epistles. This was also the praenomen of all three Roman emperors of the 1st-century Flavian dynasty, and it is the name by which the second of them is commonly known to history. Shakespeare later used it for the main character in his tragedy Titus Andronicus (1593). As an English name, Titus has been occasionally used since the Protestant Reformation.
A city in Italy bears this name, though in this case it originates from Latin Mediolanum, perhaps ultimately of Celtic origin meaning "middle of the plain". In some cases the city name may be an influence on the use of the given name.