As an English name, it was occasionally used during the Middle Ages in honour of the Old Testament heroine. It did not become common until after the Protestant Reformation, at which time it was often spelled Susan.
As an English name it has been very popular since the Middle Ages. It was the top name for girls in England and Wales in the 1920s, 30s and 40s, but it declined in the latter half of the 20th century.
Other saints by this name include a queen of Scotland and a princess of Hungary. It was also borne by Queen Margaret I of Denmark, who united Denmark, Sweden, and Norway in the 14th century. Famous literary bearers include American writer Margaret Mitchell (1900-1949), the author of Gone with the Wind, and Canadian writer Margaret Atwood (1939-). Others include American anthropologist Margaret Mead (1901-1978) and British prime minister Margaret Thatcher (1925-2013).
Despite this potentially negative association, the name was occasionally used by Christians during the Middle Ages. In the English-speaking world both Eve and the Latin form Eva were revived in the 19th century, with the latter being more common.
There was a medieval English form of this name, Helewis, though it died out after the 13th century. In the 19th century it was revived in the English-speaking world in the form Eloise.
The name was borne by a 17th-century English queen and also by the second wife of Henry VIII, Anne Boleyn (the mother of Queen Elizabeth I), who was eventually beheaded in the Tower of London. Another notable bearer was the German-Jewish diarist Anne (Annelies) Frank, a young victim of the Holocaust in 1945. This is also the name of the heroine in the 1908 novel Anne of Green Gables by Canadian author L. M. Montgomery.