Due to the renown of the saint, this name became widespread in Western Europe during the Middle Ages. However, it was not regularly used in Britain until the 16th century. Famous bearers include Saint Francis Xavier (1506-1552), a missionary to East Asia, the philosopher and scientist Francis Bacon (1561-1626), the explorer and admiral Francis Drake (1540-1595), and Pope Francis (1936-).
In the English-speaking world this name is occasionally used for girls, as a variant of the homophone Frances.
The most notable bearer of the name was Cyrus the Great, the founder of the Achaemenid Persian Empire in the 6th century BC. He is famous in the Old Testament for freeing the captive Jews and allowing them to return to Israel after his conquest of Babylon. As an English name, it first came into use among the Puritans after the Protestant Reformation.