Well Zeke rhymes with geek, reek, weak, freak etc. So if you were in school in England you would be in for LOADS of teasing! People just have to think whether the name they are about to choose for their son or daughter rhymes with anything horrible or is open for teasing.
I like the sound of this name, but find the original, Ezekiel, to sound a bit "nerdy". If I was to use this name for my child, I'd change the spelling to Xeke.