Francisca Reyes-Aquino (1899 – 1983) was a Filipino folk dancer and academic noted for her research on Philippine folk dance. She is a recipient of the Republic Award of Merit and the Ramon Magsaysay Award and is a designated National Artist of the Philippines for Dance.
Francisca (1694-1694) was the daughter of King Pedro II of Portugal and his second wife Marie Sophie. She died young. Her younger sister (1699-1736) was also named Francisca.
Francisca Ballesteros (born 1969) is a Spanish serial killer, who gained notoriety for killing her two daughters and her husband, as well as trying to kill her son, between 1990 and 2004.