I think in English it would be more like (mel-YOU-seen). An English pronunciation key for Melusine is not provided on this site. But to go step by step, mel as in Melon YOU as in the word you and seen. That's how the Americans and Brits in my French lit class usually said it when speaking English.
Edited: I didn't see Lumia's post. Sorry.
http://legitnames.blogspot.comThis message was edited 8/27/2009, 2:36 PM