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Isaza is a Basque surname, and Isasi, Izasa, and Izatza are other spellings that have become surnames in Spain. It is probably originally from the Basque word isats, "broom plant".

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This information is from a combination of Diccionario etimologico comparado de los appellidos Espanoles, Hispanoamericanos y Filipinos by Gutierre Tibon, and A Dictionary of Surnames by Hanks & Hodges.