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Karlis is the Latvian form of Charles and in my experience is usually a male name. The main Karlis I am familiar with is Dr. Karlis Osis, a Latvian-born parapsychologist:

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http://www.llewellyn.com/bookstore/article.php?id=62

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I can see how some American parents hearing or seeing the name could think of it as a feminine form for Karl, however, as it seems to fit in with names like Doris, Ardis, Corliss, etc.