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This was my former boss’ wife’s name, and I always thought it was very unfortunate.

It looks more authentic with the -i- spelling. I far prefer it as a f name, with an -e on the end, also with -i- rther than -y-.

Not a fan but I guess Ghislain would be my pick.

I prefer Guilène, but it's feminine.
As for masculine — Ghislain, it looks neater, imo.
(Honestly, I don't like it on a guy).

I find the sound unattractive, the meaning strange, and the association with Ghislaine Maxwell unavoidable. Ghislain is more intuitive, but Ghyslain less reminiscent of Maxwell.