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Mia and Piper: they would never, IMO, have become popular if not for Mia Farrow and Piper Laurie. It just took a generation or two before they sounded normal enough to use for characters, and then babies.
Sia
Dustin (Hoffman)
Calista (Flockhart)
Aidan (Quinn) - at least it was basically unheard-of in the US. Liam as well, before Neeson.

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- mirfak