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I don't think Isidor/e seems at all feminine. I wouldn't let that put me off liking a name at least - there is nothing wrong with sounding feminine. It might put me off actually using it if that would cause confusion. But in this case I don't think it's a problem at all.
I have to agree that Isidorian looks like an adjective and I think it loses some of Isidor/e's strengh and charm.