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I adore both Roxanne and Roxana. I also like Roksana, the Russian version. I would spell the names exactly as I have them, although I suppose Roxanna would also work. Roxy is an adorable nickname, but I really can't see it on its own. Sounds more like a full name for a dog.

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I don't know anyone named Roxy, Roxie, Roxane, Roxanne, Roxana, or Roxanna! I think that's part of the name's charm; it's familiar but unusual. Other nicknames could be Anna or Annie; I could even see Rosie.

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I don't think I see it in the top 100, but you never know...