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The thing with a name ending in 's' like that is there needs to be a clear distinction between the last letter of the first name and the first letter of the middle name.
Iris Annemarie, Iris Helen, Iris Diane, Iris Evadne, Iris Georgina, Iris Georgine, Iris Elaine, Iris Hildegarde, Iris Angeline, Iris Juliet, Iris Olive, Iris Theodora, Iris Wilhelmina, Iris Viola, Iris Charity, Iris Amelie, Iris Juliane, Iris Olivia, Iris Heather, Iris Andromache, Iris Euphrosyne, Iris Evanthe, Iris Euphemia, Iris Eleonora, Iris Evangeline, Iris Evangelina, Iris Eudora, Iris Anamaria, Iris Euphrasie. For totally unbiased reasons, I would say Helen flows perfectly with Iris.